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Angiopoietin in experimental sepsis

 

 

    1.    Baffert F, Le T, Thurston G and McDonald DM: Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am J Physiol Heart Circ Physiol 2006, (290):H107-H118.

    2.    Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P and Augustin HG: Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 2006, (12):235-239.

    3.    Huang YQ, Sauthoff H, Herscovici P, Pipiya T, Cheng J, Heitner S, Szentirmai O, Carter B and Hay JG: Angiopoietin-1 increases survival and reduces the development of lung edema induced by endotoxin administration in a murine model of acute lung injury. Crit Care Med 2008, (36):262-267.

    4.    Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE and Sukhatme VP: Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem 2007, (282):23910-23918.

    5.    Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA and Sukhatme VP: Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006, (3):e46.

    6.    Roviezzo F, Tsigkos S, Kotanidou A, Bucci M, Brancaleone V, Cirino G and Papapetropoulos A: Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage. J Pharmacol Exp Ther 2005, (314):738-744.

    7.    Witzenbichler B, Westermann D, Knueppel S, Schultheiss HP and Tschope C: Protective role of angiopoietin-1 in endotoxic shock. Circulation 2005, (111):97-105.