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Angiopoietin as a biomarker in angiogenesis, inflammation and critically illness



        1.    Gallagher DC, Bhatt RS, Parikh SM, Patel P, Seery V, McDermott DF, Atkins MB and Sukhatme VP: Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak. Clin Cancer Res 2007, (13):2115-2120.

        2.    Gallagher DC, Parikh SM, Balonov K, Miller A, Gautam S, Talmor D and Sukhatme VP: Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock 2008, (29):656-661.

        3.    Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND and Pittet JF: Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma? Ann Surg 2008, (247):320-326.

        4.    Giuliano JS, Jr., Lahni PM, Bigham MT, Manning PB, Nelson DP, Wong HR and Wheeler DS: Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass. Intensive Care Med 2008, (.

        5.    Giuliano JS, Jr., Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM and Wheeler DS: Admission angiopoietin levels in children with septic shock. Shock 2007, (28):650-654.

        6.    Kumpers P, David S, Haubitz M, Hellpap J, Horn R, Brocker V, Schiffer M, Haller H and Witte T: The Tie2 receptor antagonist Angiopoietin-2 facilitates vascular inflammation in Systemic Lupus Erythematosus. Ann Rheum Dis 2008, (doi:10.1136/ard.2008.094664-epub ahead of print.

        7.    Kumpers P, Koenecke C, Hecker H, Hellpap J, Horn R, Verhagen W, Buchholz S, Hertenstein B, Krauter J, Eder M, David S, Gohring G, Haller H and Ganser A: Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies. Blood 2008, (112):2139-2148.

        8.    Kumpers P, Lukasz A, David S, Horn R, Hafer C, Faulhaber-Walter R, Fliser D, Haller H and Kielstein JT: Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care 2008, (12):R147.

        9.    Lee CY, Tien HF, Hu CY, Chou WC and Lin LI: Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia. Br J Cancer 2007, (97):877-882.

      10.    Lim HS, Lip GY and Blann AD: Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis. Atherosclerosis 2005, (180):113-118.

      11.    Lukasz A, Hellpap J, Horn R, Kielstein JT, David S, Haller H and Kumpers P: Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays. Crit Care 2008, (12):R94.

      12.    Martinelli S, Maffei R, Castelli I, Santachiara R, Zucchini P, Fontana M, Bonacorsi G, Leonardi G, Marasca R and Torelli G: Increased expression of angiopoietin-2 characterizes early B-cell chronic lymphocytic leukemia with poor prognosis. Leuk Res 2008, (32):593-597.

      13.    Nadar SK, Blann A, Beevers DG and Lip GY: Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]. J Intern Med 2005, (258):336-343.

      14.    Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C, Zakynthinos S, Armaganidis A, Papapetropoulos A and Roussos C: Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit Care Med 2007, (35):199-206.

      15.    Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA and Sukhatme VP: Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006, (3):e46.

      16.    Schliemann C, Bieker R, Padro T, Kessler T, Hintelmann H, Buchner T, Berdel WE and Mesters RM: Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia. Haematologica 2006, (91):1203-1211.

      17.    Schliemann C, Bieker R, Thoennissen N, Gerss J, Liersch R, Kessler T, Buchner T, Berdel WE and Mesters RM: Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia. Leukemia 2007, (21):1901-1906.

      18.    van der Heijden M, Nieuw Amerongen GP, Koolwijk P, van Hinsbergh VW and Groeneveld AJ: Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax 2008, (.